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AAAD action is expressed as the levels of dopamine [in nmol·(mg protein)−1·h−one] shaped for the duration of a offered incubation time period. Symbols and vertical lines characterize suggest ± SEM of nA sub-group of POTS sufferers are believed to possess partial sympathetic denervation and compensatorily greater cardiac sympathetic outflow [
This reactive epoxide intermediate may respond with amino acid residues of the CYP enzyme to variety drug-CYP (drug-protein) adducts (Plan six, pathway C). The development from the drug-CYP adducts may or may not exhibit a time-dependent inactivation with the catalytic exercise of the CYP enzyme, based on the covalent binding in the reactive interm
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